Ola Alyazidi

Bioinformatics Specialization · Cohort 2024

Investigating the Role of the X-Chromosome in Autoimmune Diseases: A Bioinformatics Approach Leveraging Single-Cell Genomics

Autoimmune diseases predominantly affect women, suggesting a potential role for the X chromosome in disease susceptibility. This study investigates the involvement of the X chromosome in autoimmune diseases using single-cell RNA sequencing data. By analyzing gene expression patterns across immune cells from patients with Crohn’s disease and type 1 diabetes, we identified differentially expressed genes (DEGs) located on the X chromosome. Our findings reveal a notable proportion of DEGs associated with the X chromosome, underscoring its potential contribution to the pathogenesis of these conditions. This research provides new insights into the molecular mechanisms underlying autoimmune diseases and highlights the need for further exploration of X-linked genetic factors.

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