Raiyan Subedar

Summer project

Bioinformatics Specialization · Cohort 2026

Counting Studies vs. Combining Them: Re-Analyzing 28 Gut-Microbiome Studies

A reproduction and re-analysis of a widely cited gut microbiome meta-analysis. The original identified bacterial genera shared across diseases by counting how many studies reached significance — a rule that ignores effect size and cannot tell agreement from contradiction. This project pools effect sizes instead, quantifies between-study disagreement, and tests whether the signal generalizes to unseen cohorts.

Read the final report (PDF)

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