After KAUST Academy
Saad is a medical student at the University of Tabuk as of October 2026.
Summer project
Bioinformatics Specialization · Cohort 2025
Identifying Differentially Expressed Genes Shared Between Progressive Types of Multiple Sclerosis to Uncover Drivers of Disease Progression
This project aims to identify differentially expressed genes shared between the progressive forms of Multiple Sclerosis (MS); Primary Progressive MS (PPMS) and Secondary Progressive MS (SPMS) to better understand the molecular mechanisms driving disease progression. A bulk RNA-seq transcriptomic analysis was conducted using publicly available brain tissue data (GEO accession: GSE290552). The data were analyzed using DESeq2, with pairwise comparisons between MS subtypes. Venn diagrams were used to identify and visualize genes uniquely shared between the progressive types. To further interpret the biological relevance of these findings, a literature review was conducted to investigate the potential roles of the identified genes in the context of Multiple Sclerosis.
Mentor: Hugo Tavares, Andries J. van Tonder
With KAUST Academy
- Cohort 2025
University of Cambridge · Bioinformatics Summer Program
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