Summer project
Bioinformatics Specialization · Cohort 2025
Therapeutic Targets in Ovarian Cancer: Proliferative (C1) vs Differentiated (C4) Subtypes
This project explored proteomic differences between the proliferative (C1) and differentiated (C4) subtypes of high-grade serous ovarian carcinoma using CPTAC datasets. By applying PCA, heatmaps, and differential expression analysis with limma, we identified subtype-specific proteins and pathways. Enrichment analysis revealed that C1 tumors are enriched in ribosomal and DNA replication proteins, while C4 tumors show detoxification and immune-related processes. Finally, drug–target mapping highlighted potential therapeutic opportunities, suggesting that C1 and C4 may require different treatment strategies. This work emphasizes the importance of proteomics in guiding personalized therapy for ovarian cancer
Mentor: Dr. Lajos Kalma
With KAUST Academy
- Cohort 2025
University of Cambridge · Bioinformatics Summer Program
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