بعد أكاديمية كاوست
Mona is studying at King Saud University and heads the 3D Design Committee at 3DCKSU. In September 2026, Mona completed the KAUST Academy Specializations Program, after being accepted into the Bioinformatics summer stage.
المشروع الصيفي
تخصص المعلوماتية الحيوية · دفعة 2026
Evaluating Binding Predictors for Aptamer Discovery: Construction Gaps in Interaction Benchmarks
Computational tools that predict whether an aptamer binds a target protein could accelerate aptamer discovery by shortlisting candidates before experimental testing. To be useful, predictors must work on proteins they have never seen. In this project, we investigated AptaTrans, a widely cited binding predictor reporting a ROC-AUC of 0.921. We re-curated its dataset and evaluated it under different ways of separating training and test data, including a setup where the model encountered entirely new protein targets during testing. We found that its performance depended strongly on whether the target protein had appeared during training, with performance on new targets close to chance. We also investigated how the training data and protein representations affected these results. Overall, the project highlights the difference between ranking aptamers for familiar targets and discovering binders for new ones, while providing a re-curated dataset and evaluation protocol for more rigorous testing.
مع أكاديمية كاوست
- دفعة 2026
جامعة الملك خالد · المدرسة الصيفية للمعلوماتية الحيوية
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